Experienced team focused on inhibiting inflammatory cell death underlying a range of severe inflammatory diseases
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Quench Scientific Advisor Sam Xiao and colleagues describe the structural interaction of human caspase-1 with full-length murine Gasdermin D, revealing an exosite interface.
In this publication, the Abbott Lab and Sam Xiao identify loss-of-function SNPs in GSDMD. Changes in single amino acids that decrease or eliminate pore formation demonstrate that even large and organized molecular complexes have linchpins.
In this review, Quench Scientific Advisor Kate Fitzgerald and colleagues discuss the science of gasdermin proteins, with particular emphasis on Gasdermin D and its mechanism of action and biological significance.
Quench Scientific Advisor Sam Xiao’s lab reports the crystal structure of full-length murine and human Gasdermin D, providing a framework for understanding the autoinhibition, lipid binding and oligomerization of Gasdermin D.