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Rathkey, J., Xiao, T., and Abbott, D. Human polymorphisms in Gsdmd alter the inflammatory response. J Biological Chemistry. January 2020.

In this publication, the Abbott Lab and Sam Xiao identify loss-of-function SNPs in GSDMD. Changes in single amino acids that decrease or eliminate pore formation demonstrate that even large and organized molecular complexes have linchpins.

Orning, P., Lien, E., and Fitzgerald, K.A. Gasdermins and their role in immunity and inflammation. J Exp Med. Nov 2019.

In this review, Quench Scientific Advisor Kate Fitzgerald and colleagues discuss the science of gasdermin proteins, with particular emphasis on Gasdermin D and its mechanism of action and biological significance.